Published by:
CGP EDU Academic Team
Published on: August 13, 2026
Which of the following is correct about thalassemia and sickle cell anemia?
A
Sickle cell anaemia is a quantitative problem of synthesizing an incorrectly functioning globin, while thalassemia is a qualitative problem of synthesizing too few globin molecules.
B
Sickle cell anaemia is due to a mutation in a single gene, while 
-thalassemia is due to either a mutation or deletion and is controlled by two genes.
-thalassemia is due to either a mutation or deletion and is controlled by two genes. C
Sickle cell anaemia results in the formation of abnormal haemoglobin, while thalassemia does not.
D
Sickle cell anaemia results in a reduction in normal RBC count, while thalassemia does not cause anaemia.
Text Solution
Verified by ExpertsThe correct answer is:
B
Thalassemia differs from sickle-cell anaemia in that the former is a quantitative problem of synthesising too few globin molecules while the latter is a qualitative problem of synthesising an incorrectly functioning globin. Thalassemia also results in abnormal haemoglobin, but the abnormality is quantitative (less globin chains) rather than structural. Both sickle cell anaemia and thalassemia results in anaemia.
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